Search
Invitrogen
MMP14 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}:
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96159
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.17 mg/mL
Amount
217 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: THP-1, NCI-H460, Mouse liver; Cellular Location: Cytoplasm, Melanosome, Membrane, Single-pass type I membrane protein
Immunogen sequence: QVTGKADADT MKAMRRPRCG VPDKFGAEIK ANVRRKRYAI QGLKWQHNEI TFCIQNYTPK VGEYATYEAI RKAFRVWESA TPLRFREVPY AYIREGHEKQ
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMPs; MT-MMP 1; MT-MMP MT1-MMP; MT-MMP-1; MT1-MMP; MMP-14; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14; unnamed protein product
Gene Aliases: MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; MTMMP1; sabe; WNCHRS
UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739
Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707
skeletal system development
ossification
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
cell proliferation
male gonad development
response to mechanical stimulus
response to hormone
positive regulation of myotube differentiation
positive regulation of protein processing
cell migration
protein catabolic process
extracellular matrix organization
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
tube morphogenesis
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
cell motility
negative regulation of focal adhesion assembly
head development
bone development
cellular response to genistein
craniofacial suture morphogenesis
GDF15-GFRAL signaling pathway
negative regulation of GDF15-GFRAL signaling pathway
regulation of protein localization to plasma membrane
positive regulation of macrophage migration
response to odorant
anatomical structure morphogenesis
protein processing
extracellular matrix disassembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support