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Invitrogen
TADA3L Polyclonal Antibody
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Product Details
PA5-96535
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 270-369 of human TADA3 (NP_5978141)
Conjugate
Form
Liquid
Concentration
0.59 mg/mL
Amount
59 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EENIISPMED SPIPDMSGKE SGADGASTSP RNQNKPFSVP HTKSLESRIK EELIAQGLLE SEDRPAEDSE DEVLAELRKR QAELKALSAH NRTKKHDLLR; Positive Samples: HT-29, BxPC-3, HepG2, HeLa, Mouse testis, Mouse liver, Rat testis, Rat liver; Cellular Location: Nucleus
Target Information
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; epididymis secretory sperm binding protein; FLJ20221; FLJ21329; hADA3; mADA3; STAF54; TADA3L; Transcriptional adapter 3; Transcriptional adapter 3-like; unnamed protein product
Gene Aliases: 1110004B19Rik; ADA3; AI987856; hADA3; NGG1; STAF54; TADA3; TADA3L
UniProt ID: (Human) O75528, (Rat) Q4V8F5, (Mouse) Q8R0L9
Entrez Gene ID: (Human) 10474, (Rat) 362414, (Mouse) 101206
transcription coactivator activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
histone acetyltransferase activity
ligand-dependent nuclear receptor transcription coactivator activity
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
mitotic cell cycle
regulation of DNA repair
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
intracellular estrogen receptor signaling pathway
regulation of protein stability
regulation of RNA splicing
positive regulation of transcription, DNA-templated
regulation of embryonic development
regulation of cell division
regulation of cell cycle
regulation of protein phosphorylation
transcription, DNA-templated
mitotic nuclear division
biological_process
regulation of histone deacetylation
histone H3 acetylation
regulation of tubulin deacetylation
regulation of nucleic acid-templated transcription
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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