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Invitrogen
KPNA6 Polyclonal Antibody
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FIGURE: 1 / 1
KPNA6 Antibody (PA5-96654) in WB
Western blot analysis of KPNA6 in various lysates. Samples were incubated with KPNA6 Polyclonal antibody (Product # PA5-96654) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 277-536 of human KPNA6 (NP_0364481)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.25 mg/mL
Amount
125 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SYLSDGPNEK IQAVIDSGVC RRLVELLMHN DYKVASPALR AVGNIVTGDD IQTQVILNCS ALPCLLHLLS SPKESIRKEA CWTISNITAG NRAQIQAVID ANIFPVLIEI LQKAEFRTRK EAAWAITNAT SGGTPEQIRY LVSLGCIKPL CDLLTVMDSK IVQVALNGLE NILRLGEQEG KRSGSGVNPY CGLIEEAYGL DKIEFLQSHE NQEIYQKAFD LIEHYFGVED DDSSLAPQVD ETQQQFIFQQ PEAPMEGFQL; Positive Samples: BT-474, SW620, U-251MG, Mouse testis
Target Information
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ11249; importin alpha 7; importin alpha 7 subunit; importin alpha-S2; importin-alpha-S2; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); Kpna6; MGC17918; RP4-622L5.1; unnamed protein product
Gene Aliases: IPOA7; Kpna5; NPI-2
UniProt ID: (Human) O60684, (Mouse) O35345
Entrez Gene ID: (Human) 23633, (Mouse) 16650
protein import into nucleus
NLS-bearing protein import into nucleus
entry of viral genome into host nucleus through nuclear pore complex via importin
positive regulation of viral life cycle
viral genome replication
evasion or tolerance of host defense response
positive regulation of transcription from RNA polymerase II promoter
maternal process involved in female pregnancy
positive regulation of cytokine production involved in inflammatory response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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