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Invitrogen
alpha Adducin Polyclonal Antibody
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FIGURE: 1 / 2
alpha Adducin Antibody (PA5-99523) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded alpha Adducin in human brain tissues sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with alpha Adducin polyclonal antibody (Product # PA5-99523) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99523
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADD1(Accession P35611), corresponding to amino acid residues G700-S737.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ADD1.
Target Information
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; alpha-ADD; alpha-adducin 1; beta Adducin; Beta-adducin; calmodulin-binding protein; cytoskeletal protein; erythrocyte adducin alpha subunit; erythrocyte adducin subunit alpha; unnamed protein product
Gene Aliases: ADDA
UniProt ID: (Human) P35611, (Mouse) Q9QYC0, (Rat) Q63028
Entrez Gene ID: (Human) 118, (Mouse) 11518, (Rat) 24170
RNA binding
actin binding
protein binding
cytoskeletal adaptor activity
spectrin binding
protein homodimerization activity
cadherin binding
protein heterodimerization activity
protein dimerization activity
actin filament binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
structural constituent of cytoskeleton
T cell receptor binding
cell morphogenesis
in utero embryonic development
cell volume homeostasis
cytoskeleton organization
hemoglobin metabolic process
actin cytoskeleton organization
erythrocyte differentiation
negative regulation of actin filament polymerization
regulation of cellular component size
multicellular organism growth
positive regulation of angiogenesis
positive regulation of endocytosis
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
positive regulation of developmental process
positive regulation of cellular component organization
cellular response to calcium ion
cellular response to retinoic acid
positive regulation of establishment of endothelial barrier
positive regulation of adherens junction organization
regulation of multicellular organismal development
ion transport
regulation of actin filament polymerization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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