Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Phospho-ILK (Ser343) Polyclonal Antibody

View all (35) ILK antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-ILK (Ser343) Polyclonal Antibody

Product Details

PA5-99568

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ILK(Accession Q13418), corresponding to amino acid residues around phosphorylated Ser343.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818501

Product Specific Information

Antibody detects endogenous levels of ILK only when phosphorylated at Ser343.

Target Information

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK; inactive integrin-linked kinase; integrin binding protein kinase; Integrin linked ILK; integrin-linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; unnamed protein product

View more View less

Gene Aliases: ESTM24; HEL-S-28; ILK-1; ILK-2; P59; p59ILK

View more View less

UniProt ID: (Human) Q13418, (Rat) Q99J82, (Mouse) O55222

View more View less

Entrez Gene ID: (Human) 3611, (Rat) 170922, (Mouse) 16202

View more View less

Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity receptor binding integrin binding protein binding ATP binding protein kinase binding protein binding, bridging SH3 domain binding protein domain specific binding macromolecular complex binding
Process(es)
cell morphogenesis outflow tract morphogenesis mitotic spindle organization cell-matrix adhesion integrin-mediated signaling pathway anatomical structure morphogenesis positive regulation of signal transduction cell differentiation positive regulation of BMP signaling pathway tumor necrosis factor-mediated signaling pathway substrate adhesion-dependent cell spreading positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated actin filament bundle assembly actin filament network formation platelet aggregation caveola assembly protein localization to cell cortex positive regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading regulation of cell growth branching involved in ureteric bud morphogenesis positive regulation of cell-matrix adhesion protein phosphorylation negative regulation of protein kinase activity positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process fibroblast migration Schwann cell development negative regulation of smooth muscle cell migration peptidyl-serine phosphorylation nerve development myelination in peripheral nervous system positive regulation of cell migration regulation of actin cytoskeleton organization negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of myoblast differentiation positive regulation of axon extension negative regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of axonogenesis positive regulation of dendrite morphogenesis positive regulation of protein kinase B signaling fibril organization negative regulation of neural precursor cell proliferation positive regulation of cellular senescence
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support