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TAUT Polyclonal Antibody
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FIGURE: 1 / 2
TAUT Antibody (PA5-99725) in IHC (P)
Immunohistochemistry analysis of TAUT in rat skin tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with TAUT polyclonal antibody (Product # PA5-99725) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99725
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC6A6(Accession P31641), corresponding to amino acid residues I563-H613.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TAUT.
Target Information
Taurine is an abundant organic osmolyte that possesses antioxidant and immunomodulatory properties and plays a role in cell volume homeostasis. Taurine is taken up into cells via the taurine transporter (TAUT). TAUT, which is sodium- and chloride-dependent, is a multi-pass membrane protein belonging to the sodium neurotransmitter symporter (SNF) family of proteins. TNF alpha upregulates TAUT expression, while phosphorylation on Serine 322 downregulates it. Overexpression of TAUT protects renal cells from cisplatin-induced nephrotoxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC10619; MGC131729; OTTHUMP00000208177; OTTHUMP00000208180; SC6A6; solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Taurine Transporter; unnamed protein product
Gene Aliases: HTRDC; TAUT
UniProt ID: (Human) P31641
Entrez Gene ID: (Human) 6533
beta-alanine transmembrane transporter activity
sodium:amino acid symporter activity
gamma-aminobutyric acid:sodium symporter activity
taurine:sodium symporter activity
amino acid transmembrane transporter activity
gamma-aminobutyric acid transmembrane transporter activity
alanine transmembrane transporter activity
beta-alanine transport
neurotransmitter transport
amino acid transport
taurine transport
alanine transport
sodium ion transmembrane transport
positive regulation of cell differentiation
modulation of synaptic transmission
gamma-aminobutyric acid import
positive regulation of mitochondrial translation
amino acid import across plasma membrane
import across plasma membrane
transport across blood-brain barrier
negative regulation of cellular senescence
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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