Noggin Recombinant Human Protein

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Recombinant Human Noggin is a bioactive protein intended for use in cell culture applications. Noggin binds and inactivates members of the transforming growth factor-beta (TGF-β) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-β superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Noggin is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Noggin specific activity is determined by measuring the dose dependent inhibition of the 5 ng/ml BMP-4-induced alkaline phosphatase production by ATDC-5 chondrogenic cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.
For Research Use Only. Not for use in diagnostic procedures.


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Species: Human
Product Size: 20 µg
Protein Form: Recombinant
Protein Subtype: Other Proteins
Research Category: Neurobiology, Stem Cell Research, Development, Differentiation
Validated Application: Cell Culture
Protein Length or Portion (a.a.): 412 aa (homodimer)
Shipping Condition: Approved for shipment on Wet or Dry Ice

Contents & storage

Store in freezer (-5 to -30°C).


Manuals & protocols

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