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KIT [V654A] Recombinant Human Protein

Catalog number:  PR7738A

Related applications:

Protein Assays and Analysis

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Description

KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_000213, V654A
Expression: Baculovirus
Form: Frozen
Gene Aliases: KIT V654A
Kinase Family: PDGFR Kinase Family
Kinase Group: Tyrosine Kinases
Molecular Weight: 53.2 kDa
Product Size: 100 µg
Protein Form: Cytoplasmic
Protein Tag or Fusion: His Tag
Research Category: Drug Development
Shipping Condition: Dry Ice
Species: Human
Validated Application: Kinase Assay

Contents & storage

Storage Buffer: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.