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Invitrogen
Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein
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Product Details
PR8004B
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
1-596
Tag
His-tag
Molecular weight
45.8 kDa
Class
Recombinant
Type
Protein
Purity
55% by SDS-PAGE
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 0.02% Triton X-100, 50% glycerol, 2mM DTT, 0.5mM EDTA, 150mM NaCl
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
MAP3K7 (TAK1) controls transcription regulation and apoptosis, and is implicated in inflammatory disease and rheumatoid arthritis. Fusion of MAP3K7 to MAP3K7IP1 (TAB1) activates MAP3K7. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitogen-activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAB1beta; TAK1; TAK1-binding protein 1; TAK1d; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; Transforming growth factor-beta-activated kinase 1; unnamed protein product
Gene Aliases: 3'-Tab1; CSCF; FMD2; MAP3K7; MAP3K7IP1; MEKK7; TAB1; TAK1; TGF1a
UniProt ID: (Human) O43318, (Human) Q15750
Entrez Gene ID: (Human) 6885, (Human) 10454
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