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Thermo Scientific™

EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein

Catalog number:  PR8911A

Related applications:

Protein Assays and Analysis

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Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2; T790M L858R
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
Expression System: Baculovirus
Form: Frozen
Protein Form: Cytoplasmic
Research Category: Drug Development
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 90.6 kDa
Gene Alias: EGFR (ErbB1) T790M L858R
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.