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Thermo Scientific™

CHEK2 (CHK2) Recombinant Human Protein

Catalog number:  PV3367

Related applications:

Protein Assays and Analysis

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Description

CHEK2 (CHK2) is a serine⁄threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in this gene has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_009125
Assay Entry: Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Ser⁄Thr Kinases: CAMK Group
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry: CHEK2
Target Gene: CHK2 checkpoint homolog
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Full Length, Recombinant
Protein Subtype: Serine⁄Threonine Kinases
Research Category: Signal Transduction, DNA Replication & Repair, Oncology
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 11200
Molecular Weight: 66 kDa
Gene Alias: CHEK2 (CHK2)
KinaseFamily: RAD53 Kinase Family
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.04% Triton X-100, 4mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.