Beta-Lactamase (TEM-1) Protein

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TEM-1 beta-lactamase is the most widespread enzyme to confer beta-lactam antibiotic resistance to gram-negative bacteria. It is a monomeric protein that requires no metals or cofactors for activity. TEM-1 beta-lactamase efficiently hydrolyzes most penicillin and cephalosporin substrates, including nitrocefin and fluorescent derivates. This protein is intended to be used as a positive control for enzyme-dependent substrate hydrolysis and for use on immunoblots. Other uses include kinetic studies with novel substrates or identification of inhibitors of beta-lactamase as part of an antimicrobial program.
For Research Use Only. Not for use in diagnostic procedures.


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Product Size: 10 µg
Protein Subtype: Other Proteins
Research Category: Toxicology & Drug Metabolism
Validated Application: Assay Standard
Shipping Condition: Dry Ice

Contents & storage

Store in ultra-cold freezer (-68 to -85°C).


Manuals & protocols

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