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The PKC family of serine⁄threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
For Research Use Only. Not for use in diagnostic procedures.
Ser⁄Thr Kinases: AGC Group
PKC Kinase Family
Contents & Storage
Storage Buffer: 20mM HEPES, pH 7.5, 250mM NaCl, 2mM EDTA, 2mM EGTA, 5mM DTT, 0.05% Triton X-100, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.