For order quantities > 1, multiple lots may be used to fulfill the order. If you require a single lot, please email to ensure your needs are accommodated

88 more kinases now available to order! See the complete list.

RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Your price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}}
also known as {{product.formattedSku}} 
{{subscriptionDetails.selectedRatePlan.billingPeriod}} {{subscriptionDetails.selectedRatePlan.billingPeriod}} {{product.availability.message}}
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top


RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
For Research Use Only. Not for use in diagnostic procedures.


Gene ID: 4773, 5894
Species: Human
Target Gene: v-raf-1 murine leukemia viral oncogene homolog 1
Gene Aliases: RAF1 (cRAF) Y340D Y341D
Kinase Group: Ser⁄Thr Kinases: TKL Group
Product Size: 10 µg
Protein Family: Kinases & Inhibitors
Protein Subtype: Serine⁄Threonine Kinases
Accession Number: NP_002871, Y340D, Y341D
Molecular Weight: 66.4 kDa
Research Category: Signal Transduction
System Compatibility: LanthaScreen® Substrate, Omnia® Bulk Substrate, LanthaScreen® Antibody, Z'-LYTE™
Validated Application: Kinase Assay
Protein Length or Portion (a.a.): aa 306-648; Y340D, Y341D
Protein Tag or Fusion: GST Tag
Expression: Baculovirus
Kinase Family: RAF Kinase Family
Protein Form: Catalytic, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.


Manuals & protocols