For order quantities > 1, multiple lots may be used to fulfill the order. If you require a single lot, please email discoverysciences@lifetech.com to ensure your needs are accommodated

88 more kinases now available to order! See the complete list.
Thermo Scientific™

EGFR (ErbB1) [L861Q] Recombinant Human Protein

Catalog number:  PV3873

Related applications:

Protein Assays and Analysis

Back to top

Description

The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2; L861Q
Assay Entry: Biochemical binding/kinetic, Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group: Tyrosine Kinases
Mass: 10 µg
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position: N-Terminal
Target Entry: EGFR L861Q
Target Gene: Epidermal growth factor receptor
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 114294, 1956
Molecular Weight: 90.5 kDa
Gene Alias: EGFR (ErbB1) L861Q
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Length: aa 668-1210: L858R, aa 668-1210; L861Q
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.