MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
For Research Use Only. Not for use in diagnostic procedures.
NP_002746, S218D, S222D
MAP2K1 (MEK1) S218D S222D
STE7 Kinase Family
Ser/Thr Kinases: STE Group
Contents & Storage
Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.05 mM EDTA, 0.05% NP-40, 1mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.