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KIT [V654A] Recombinant Human Protein

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Description

KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_000213, V654A
Gene Aliases: KIT V654A
Gene ID: 3815, 4775
Kinase Group: Tyrosine Kinases
Mass: 10 µg
Molecular Weight: 53.2 kDa
Product Size: 10 µg
Protein Family: Kinases & Inhibitors
Protein Length or Portion (a.a.): aa 544-976; V654A
Protein Subtype: Receptor Tyrosine Kinases
Protein Tag or Fusion: His Tag
Research Category: Signal Transduction
Species: Human
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate
Tag Position: N-Terminal
Target Gene: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Validated Application: Kinase Assay
Expression: Baculovirus
Kinase Family: PDGFR Kinase Family
Protein Form: Cytoplasmic, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

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