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KIT [V654A] Recombinant Human Protein

Catalog number:  PV4132

Related applications:

Pharma & Biopharma

| Protein Assays and Analysis

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Description

KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_000213, V654A
Assay Entry: Biochemical binding/kinetic, Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group: Tyrosine Kinases
Mass: 10 µg
Protein Form: Recombinant, Cytoplasmic
Research Category: Signal Transduction
Shipping Condition: Dry Ice
Species: Human
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate
Tag Position: N-Terminal
Target Entry: KIT V654A
Target Gene: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene ID (Entrez): 3815, 4775
Molecular Weight: 53.2 kDa
Protein Subtype: Receptor Tyrosine Kinases
Gene Alias: KIT V654A
Validated Application: Kinase Assay
Protein Family: Kinases & Inhibitors
Expression System: Baculovirus
KinaseFamily: PDGFR Kinase Family
Protein Length: aa 544-976; V654A
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.