The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Accession Number
NP_005219.2; L861Q
Molecular Weight
90.5 kDa
Quantity
1 mg
Gene Alias
EGFR (ErbB1) L861Q
KinaseFamily
EGF Receptor (ErbB) Kinase Family
Recombinant
Yes
Protein Tag
GST Tag
Kinase Group
Tyrosine Kinases
Shipping Condition
Dry Ice
Expression System
Baculovirus
Protein Form
Cytoplasmic
Form
Frozen
Protein Subtype
EGF (Epidermal Growth Factor)
Validated Application
Kinase Assay
Species
Human
Research Category
Drug Development
Contents & Storage
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.