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FGFR3 [K650E] Recombinant Human Protein

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Description

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Protein Family: Kinases & Inhibitors
Research Category: Oncology, Signal Transduction
Accession Number: NP_000133; K650E
Gene Aliases: FGFR3 K650E
Kinase Group: Tyrosine Kinases
Mass: 10 µg
Molecular Weight: 49.8 kDa
Product Size: 10 µg
Protein Length or Portion (a.a.): aa 398-806; K650E
Protein Subtype: Receptor Tyrosine Kinases
Protein Tag or Fusion: His Tag
Species: Human
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Omnia® Bulk Substrate, Z'-LYTE™
Tag Position: N-Terminal
Target Gene: fibroblast growth factor receptor 3
Validated Application: Kinase Assay
Expression: Baculovirus
Kinase Family: FGF Receptor Kinase Family
Protein Form: Cytoplasmic, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

Documents

Manuals & protocols