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FGFR3 [K650E] Recombinant Human Protein

Catalog number:  PV4392

Related applications:

Protein Biology

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Description

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_000133; K650E
Assay Entry: Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Tyrosine Kinases
Mass: 10 µg
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position: N-Terminal
Target Entry: FGFR3 K650E
Target Gene: fibroblast growth factor receptor 3
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 49.8 kDa
Gene Alias: FGFR3 K650E
KinaseFamily: FGF Receptor Kinase Family
Protein Length: aa 398-806; K650E
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.