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Thermo Scientific™

EGFR (ErbB1) [T790M] Recombinant Human Protein

Catalog number:  PV4803

Related applications:

Protein Assays and Analysis

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Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2; T790M
Assay Entry: Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry: EGFR T790M
Target Gene: Epidermal growth factor receptor
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 1956
Molecular Weight: 90.5 kDa
Gene Alias: EGFR (ErbB1) T790M
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Length: aa 668-1210; T790M
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.02% Trition X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.