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EGFR (ErbB1) [T790M] Recombinant Human Protein

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Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Protein Family: Kinases & Inhibitors
Research Category: Oncology, Signal Transduction
Accession Number: NP_005219.2; T790M
Gene Aliases: EGFR (ErbB1) T790M
Gene ID: 1956
Kinase Group: Tyrosine Kinases
Molecular Weight: 90.5 kDa
Product Size: 10 µg
Protein Length or Portion (a.a.): aa 668-1210; T790M
Protein Subtype: Receptor Tyrosine Kinases
Protein Tag or Fusion: GST Tag
Species: Human
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Omnia® Bulk Substrate, Z'-LYTE™
Target Gene: Epidermal growth factor receptor
Validated Application: Kinase Assay
Expression: Baculovirus
Kinase Family: EGF Receptor (ErbB) Kinase Family
Protein Form: Cytoplasmic, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.02% Trition X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

Documents

Manuals & protocols