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EIF2AK2 (PKR) Recombinant Human Protein

Catalog number:  PV4821

Related applications:

Protein Assays and Analysis

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Description

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_002750.1
Assay Entry: Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Ser⁄Thr Kinases: Other
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate
Target Entry: EIF2AK2
Target Gene: eukaryotic translation initiation factor 2-alpha kinase 2
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Catalytic
Protein Subtype: Serine⁄Threonine Kinases
Research Category: Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 9833
Molecular Weight: 62.2 kDa
Gene Alias: EIF2AK2 (PKR)
KinaseFamily: PEK Kinase Family
Protein Length: aa 252-551
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris, pH 7.5, 50% glycerol, 0.5 mM EDTA, 0.02% Triton X-100, 150 mM NaCl, 2 mM DTT
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.