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EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Accession Number
NP_004827.3
Gene ID (Entrez)
9451
Molecular Weight
93.6 kDa
Quantity
10 µg
Gene Alias
EIF2AK3 (PERK)
KinaseFamily
PEK Kinase Family
Protein Length
aa 536-1116
Recombinant
Yes
Protein Tag
GST Tag
Assay Entry
Biochemical terbium phospho-specific activity
Kinase Group
Ser⁄Thr Kinases: Other
Shipping Condition
Dry Ice
System Compatibility
LanthaScreen™ Antibody, LanthaScreen™ Substrate
Target Entry
EIF2AK3
Target Gene
eukaryotic translation initiation factor 2-alpha kinase 3
Expression System
Baculovirus
Protein Family
Kinases & Inhibitors
Protein Form
Recombinant, Catalytic
Form
Liquid
Protein Subtype
Serine/Threonine Kinases
Validated Application
Kinase Assay
Species
Human
Research Category
Signal Transduction
Contents & Storage
Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.