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LRRK2 [D1994A] Human Protein

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Description

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.

Related Links:
LRRK2 tools for advancing Parkinson's disease research
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For Research Use Only. Not for use in diagnostic procedures.

Specifications

Protein Family: Kinases & Inhibitors
Research Category: Neurobiology, Signal Transduction
Accession Number: NP_940980.2
Gene Aliases: LRRK2 D1994A
Gene ID: 120892
Kinase Group: Ser⁄Thr Kinases: TKL Group
Molecular Weight: 205 kDa
Product Size: 10 µg
Protein Length or Portion (a.a.): aa 970-2527
Protein Subtype: Serine⁄Threonine Kinases
Species: Human
Target Gene: LRRK2
Validated Application: Kinase Assay
Protein Tag or Fusion: GST Tag
Expression: Baculovirus
Kinase Family: LRRK Kinase Family
Protein Form: Catalytic
Shipping Condition: Dry Ice

Contents & storage

Kinase proteins are shipped on dry ice and should be stored at -80°C.

Documents

Manuals & protocols