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![LRRK2 [D1994A] Human Protein](/TFS-Assets/LSG/product-images/primary-antibody-image_650.jpg-650.jpg)
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LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen™ Eu Kinase Binding Assay
• LanthaScreen™ Activity Assay
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen™ Eu Kinase Binding Assay
• LanthaScreen™ Activity Assay
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Accession Number
NP_940980.2
Gene ID (Entrez)
120892
Molecular Weight
205 kDa
Quantity
10 µg
Gene Alias
LRRK2 D1994A
KinaseFamily
LRRK Kinase Family
Protein Length
aa 970-2527
Protein Tag
GST Tag
Assay Entry
Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group
Ser⁄Thr Kinases: TKL Group
Shipping Condition
Dry Ice
Target Entry
LRRK2 D1994A
Target Gene
LRRK2
Expression System
Baculovirus
Protein Family
Kinases & Inhibitors
Protein Form
Catalytic, Mutant, Inactive
Protein Subtype
Serine/Threonine Kinases
Validated Application
Kinase Assay
Species
Human
Research Category
Signal Transduction, Neurobiology
Contents & Storage
Kinase proteins are shipped on dry ice and should be stored at -80°C.