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Thermo Scientific™

ACVR2A Human Protein

Catalog number: PV6124
Thermo Scientific™

ACVR2A Human Protein

Catalog number: PV6124
Catalog Number
PV6124
Unit Size
10 µg
Price (USD)
450.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
1,546.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,430.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV612410 µg
450.00
Your Price:
***
PR9111A100 µg
1,546.00
Your Price:
***
PV61251 mg
6,430.00
Your Price:
***
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This recombinant fusion protein consists of full-length activin A receptor kinase and a glutathione S-transferase (GST) tag. It is validated in the LanthaScreen® Eu Kinase Binding Assay. No special measures were taken to activate this kinase.
Compatible and validated with the LanthaScreen® Eu Kinase Binding Assay
Expressed in insect cells
GST tagged for use with Eu-labeled GST antibody

Easily Screen for Kinase Binding
The LanthaScreen® Eu Kinase Binding Assay is a TR-FRET assay that lets you measure inhibitor binding to non-activated kinases, perform simple off-rate measurements, and makes simple the study of type III (allosteric) inhibitors.

The LanthaScreen® Eu Kinase Binding Assay is easy to optimize and run. The assay uses a simple mix-and-read format with a single one hour incubation and no development steps. Simultaneous binding of an Alexa Fluor® conjugate or “tracer” to a tagged kinase is detected by addition of a europium-labeled anti-tag antibody, in this case anti-GST. Simultaneous binding of the tracer and antibody to the kinase results in a high degree of fluorescence resonance energy transfer (FRET), while displacement of the tracer with a kinase inhibitor results in a loss of FRET (Fig 1).

ACVR2A for the LanthaScreen Kinase Binding Assay
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII).

This insect cell-expressed recombinant fusion protein of full-length ACVR2A and GST tag has been validated in the LanthaScreen® Eu Kinase Binding Assay with these reagents:
 Tracer 236 (Cat No. PV5592)
•  Eu-labeled GST Antibody (Cat No. PV5594)

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

Related Link
•  Learn more about the LanthaScreen® Eu Binding Assay.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NP001607.1
Assay Entry
Biochemical binding/kinetic
Kinase Group
Ser⁄Thr Kinases: TKL Group
Readout
Kinetic
Shipping Condition
Dry Ice
System Compatibility
LanthaScreen™
Tag Position
N-Terminal
Target Entry
ACVR2A
Expression System
Baculovirus
Form
Frozen
Product Line
LanthaScreen™
Protein Family
Kinases & Inhibitors
Protein Form
Full Length
Protein Subtype
Serine⁄Threonine Kinases
Research Category
Signal Transduction
Species
Human
Validated Application
Kinase Assay
Gene ID (Entrez)
102581
Molecular Weight
85.3 kDa
Purification Method
Purified
Quantity
10 µg
Gene Alias
ACVR2A, ACTR2, ACTRII, ACVR2
KinaseFamily
STKR Kinase Family
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% NP-40, 2 mM DTT and 50% glycerol. Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

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