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Invitrogen
Human MAPK15 (ERK7), His Tag Recombinant Protein
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Product Details
PV6181
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
1-354
Tag
His-tag
Molecular weight
46.2 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM HEPES, pH 7.5, with 20% glycerol, 100mM NaCl, 5mM DTT, 15mM glutathione
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Human MAPK15 (ERK7), N-terminal fragment, amino acids M1-R354 (as in NCBI/Protein entry NP_620590.2), N-terminal 4xFLAG-tag sequence and C-terminal HIS8-fusion protein, expressed in Sf9 insect cells.
• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use
Related Product:
LanthaScreen™ Eu Kinase Binding Assay
Protein Form: Recombinant
The gene accession number for MAPK15 (ERK7) is NP_620590.2.
Target Information
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.24; ERK-7; ERK-8; ERK8 delta; protein kinase; MAP kinase family protein; extracellular regulated kinase 8 delta; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mitogen-activated protein kinase 15
Gene Aliases: ERK7; ERK8; MAPK15
UniProt ID: (Human) Q8TD08
Entrez Gene ID: (Human) 225689
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