AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase which is a member of the TAM (TYRO3/AXL/MER) receptor tyrosine kinase subfamily. AXL represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats and Axl transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. AXL is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Recombinant human AXL R499C (473-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

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