Thermo Scientific™

KIT [V559D T670I] Recombinant Human Protein

Catalog number: PV6316
Thermo Scientific™

KIT [V559D T670I] Recombinant Human Protein

Catalog number: PV6316
Catalog Number
PV6316
Unit Size
10 µg
Price (USD)
451.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
1,546.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,920.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV631610 µg
451.00
Your Price:
***
PV6317100 µg
1,546.00
Your Price:
***
PV63181 mg
6,920.00
Your Price:
***
Product Overview
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KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. Recombinant human KIT V559D T670I (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Assay Entry
Biochemical binding/kinetic
Kinase Group
Receptor Tyrosine Kinase
Target Entry
KIT V559D T670I
Expression System
Baculovirus
Form
Liquid
Protein Form
Recombinant
Species
Human
Validated Application
Kinase Assay
Format
Kit
Molecular Weight
75.3 kDa
Quantity
10 µg
Gene Alias
PBT, SCFR, CD117
Protein Length
aa 544-end
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.

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