Thermo Scientific™

KIT [Y823D] Recombinant Human Protein

Catalog number:  PV6322

Related applications:

Protein Assays and Analysis

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Description

KIT (c-KIT) Y823D encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2. KIT Y823D is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress. A genetic variation in KIT Y823D is associated with susceptibility to Helicobacter pylori infection. In addition, defects in KIT Y823D are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. KIT Y823D is also associated with the clinical outcome of HBV infection in Chinese adults. Recombinant human KIT Y823D (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Assay Entry: Biochemical binding/kinetic
Kinase Group: Receptor Tyrosine Kinase
Target Entry: KIT Y823D
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 75.2 kDa
Gene Alias: PBT, SCFR, CD119
Protein Length: aa 544-end
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.