Thermo Scientific™

MAP4K3 (GLK) Recombinant Human Protein

Catalog number: PV6349
Thermo Scientific™

MAP4K3 (GLK) Recombinant Human Protein

Catalog number: PV6349
Catalog Number
PV6349
Unit Size
10 µg
Price (USD)
Price: 499.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
Price: 7,650.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
Price: 1,740.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV634910 µg
Price: 499.00
Your Price:
-
PV63511 mg
Price: 7,650.00
Your Price:
-
PV6350100 µg
Price: 1,740.00
Your Price:
-
Product Overview
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Additional Information
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MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-Θ, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-Θ, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. Recombinant human MAP4K3 (1-380) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen™ Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Molecular Weight
69.6 kDa
Quantity
10 µg
Gene Alias
MAP4K3, MAPKKKK3, MEKKK3, RAB8IPL1
Protein Length
aa 1-380
Host Species
Insect
Recombinant
Yes
Protein Tag
GST Tag
Assay Entry
Biochemical binding/kinetic
Kinase Group
Serine/Threonine Kinase
Target Entry
MAP4K3 (GLK)
Expression System
Baculovirus
Protein Family
Kinases & Inhibitors
Protein Form
Recombinant, Fragment
Form
Liquid
Protein Subtype
Serine/Threonine Kinases
Validated Application
Kinase Assay
Species
Human
Research Category
Drug Discovery: Cell Cycle & Proliferation, Signal Transduction

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.