Thermo Scientific™

MAP4K3 (GLK) Recombinant Human Protein

Catalog number: PV6349
Thermo Scientific™

MAP4K3 (GLK) Recombinant Human Protein

Catalog number: PV6349
Catalog Number
PV6349
Unit Size
10 µg
Price (USD)
450.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,900.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
1,542.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV634910 µg
450.00
Your Price:
***
PV63511 mg
6,900.00
Your Price:
***
PV6350100 µg
1,542.00
Your Price:
***
Product Overview
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MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-Θ, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-Θ, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. Recombinant human MAP4K3 (1-380) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Assay Entry
Biochemical binding/kinetic
Kinase Group
Serine/Threonine Kinase
Target Entry
MAP4K3 (GLK)
Expression System
Baculovirus
Form
Liquid
Protein Form
Recombinant
Species
Human
Validated Application
Kinase Assay
Molecular Weight
69.6 kDa
Quantity
10 µg
Gene Alias
MAP4K3, MAPKKKK3, MEKKK3, RAB8IPL1
Protein Length
aa 1-380
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.

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Citations & References