MYO3B (MYO3 beta) is a member of the Class III myosins that are actin-dependent motor proteins containing an amino-terminal kinase domain. MYO3B contains a N-terminal kinase domain, followed by motor, neck, and tail domains. The MYO3B gene generates a variety of splice variants that contain 1 or 2 calmodulin-binding (IQ) motifs in the neck domain and 1 of 3 domains in the tail domain. Northern blot analysis shows expression of a 7-kb MYO3B transcript in the human retina but not in a RPE cell line. The MYO3B gene transcript is also detected in the kidney, intestine and testis. The MYO3B gene maps to chromosome 2q31.1-q31.2 by genomic sequence alignment. Recombinant human MYO3B (1-326) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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