Thermo Scientific™

ULK2 Recombinant Human Protein

Catalog number: PV6434
Thermo Scientific™

ULK2 Recombinant Human Protein

Catalog number: PV6434
Catalog Number
PV6434
Unit Size
100 µg
Price (USD)
1,546.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,920.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV6434100 µg
1,546.00
Your Price:
***
PV64351 mg
6,920.00
Your Price:
***
Product Overview
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ULK2 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Mammalian Atg13 binds ULK2 and mediates the interaction of the ULK protein with FIP200. The binding of Atg13 stabilizes and activates ULK and facilitates the phosphorylation of FIP200 by ULK. The ULK-Atg13-FIP200 complex is a direct target of mTOR and important regulator of autophagy in response to mTOR signalling. Yeast 2-hybrid assays showed the C-terminus of ULK2 binds the C-terminus of SynGAP, a negative regulator of Ras that is associated with neural development. Recombinant human ULK2 (1-478) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Kinase Group
Serine/Threonine Kinase
Expression System
Baculovirus
Form
Liquid
Protein Form
Recombinant
Species
Human
Validated Application
Kinase Assay
Molecular Weight
81.3 kDa
Quantity
100 µg
Gene Alias
Unc51.2, KIAA0623
Protein Length
aa 1-478. Contains V370M SNP
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.

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