Thermo Scientific™

PIK3CD/PIK3R1 (p110 delta/P85 alpha) Recombinant Human Protein, His tag

Catalog number: PV6452
Thermo Scientific™

PIK3CD/PIK3R1 (p110 delta/P85 alpha) Recombinant Human Protein, His tag

Catalog number: PV6452
Catalog Number
PV6452
Unit Size
100 µg
Price (USD)
1,476.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,410.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV6452100 µg
1,476.00
Your Price:
***
PV64531 mg
6,410.00
Your Price:
***
Product Overview
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Additional Information
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Phosphatidylinositol 3-kinase (PI3K) is composed of a catalytic subunit (p110δ) and a regulatory subunit (p85α in this case), which are encoded by the PIK3CD and PIK3R1 genes. PI3K phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It plays a role in oncogenic transformation and is consistently expressed at a high level in AML blast cells. PI3K can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that leads to neutrophil polarization, and regulates directional migration, but not random locomotion. The PI3K signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.

PIK3CD/PIK3R1 (p110δ/p85α) recombinant human protein is:
• Available in 3 convenient sizes
• Validated in our Adapta™ and Kinase Binding assays
• A full length protein that can help advance your research when used with validated assays

Related assay platforms:
LanthaScreen® Kinase Binding Assay
Adapta® Kinase Activity Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NP_005017.3, NP_852664.1
Shipping Condition
Dry Ice
Expression System
Baculovirus
Form
Liquid
Product Line
Life Technologies™
Protein Family
Kinases & Inhibitors
Protein Form
Full Length
Research Category
Drug Development
Species
Human
Validated Application
Kinase Assay
Gene ID (Entrez)
5293, 5295
Molecular Weight
84.7 kDa, 120.6 kDa
Quantity
100 µg
Gene Alias
p110 delta/p85 alpha, phosphoinositide-3-kinase, p110δ/p85α, regulatory subunit 1 (alpha)
Gene Symbol
PIK3CD, PIK3R1
KinaseFamily
PI3 Kinase Family
Recombinant
Yes
Protein Tag
His Tag

Contents & Storage

Storage buffer: 50 mM sodium phosphate (pH 7.0), 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol.

Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

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