PIK3CB/PIK3R1 (p110 beta/p85 alpha) Recombinant Human Protein

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Description

PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.

PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is:
• Available in 3 convenient sizes
• Validated in our Adapta® and Kinase Binding assays
• A full-length protein that can help advance your research when used in validated assays

Related assay platforms:
LanthaScreen® Kinase Binding Assay
Adapta® Kinase Activity Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Research Category: Drug Development, Oncology, Signal Transduction
Accession Number: NP_006210.1, NP_852664.1
Expression: Baculovirus
Gene Aliases: 5-bisphosphate 3-kinase, p110 beta/p85 alpha, p110β/p85α, phosphatidylinositol-4
Gene ID: PIK3CB, PIK3R1
Molecular Weight: 123.7 kDa, 84.7 kDa
Product Size: 1 mg
Protein Tag or Fusion: His Tag
Species: Human
Validated Application: Kinase Assay
Kinase Family: PI3 Kinase
Protein Form: Active, Full Length, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.

Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

Documents

Manuals & protocols