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Abnova
PRKAR1A Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01979
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human PRKAR1A.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; Carney complex type 1; epididymis secretory sperm binding protein; protein kinase A type 1a regulatory subunit; protein kinase, cAMP dependent regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; regulatory subunit RI alpha; Tissue-specific extinguisher 1; TSE1; unnamed protein product
Gene Aliases: ACRDYS1; ADOHR; CAR; CNC; CNC1; PKR1; PPNAD1; PRKAR1; PRKAR1A; Prkar1alpha; RIIA; TSE1
UniProt ID: (Human) P10644, (Rat) P09456
Entrez Gene ID: (Human) 5573, (Rat) 25725
nucleotide binding
cAMP-dependent protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase regulator activity
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
protein-binding activity modulator
kinase modulator
mesoderm formation
regulation of transcription from RNA polymerase II promoter
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
negative regulation of gene expression
positive regulation of insulin secretion
intracellular signal transduction
sarcomere organization
negative regulation of activated T cell proliferation
cardiac muscle cell proliferation
cellular response to glucagon stimulus
negative regulation of cAMP/PKA signal transduction
negative regulation of protein kinase activity
female meiotic division
negative regulation of meiotic nuclear division
regulation of protein kinase activity
negative regulation of cAMP-dependent protein kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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