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NeoBiotechnologies
SS18-SSX (Marker of Synovial Sarcoma) Recombinant Rabbit Monoclonal Antibody (SS18.SSX/12628R)
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Product Details
RBM1-12628-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SS18.SSX/12628R
Immunogen
Recombinant fragment corresponding to the fusion site of human SS18-SSX protein (exact sequence is proprietary).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The SS18/SSX fusion gene is pivotal in the pathogenesis of synovial sarcoma, a rare type of cancer typically arising in the soft tissues around joints in adolescents and young adults. The SS18-SSX fusion results from an exchange between chromosome 18's SS18 gene and one of the SSX genes (often SSX1 or SSX2 on the X chromosome), creating a hybrid protein responsible for oncogenic transformation. This fusion protein interacts with the SWI/SNF (BAF) chromatin remodeling complex, disrupting normal gene regulation and leading to tumorigenesis. Clinically, the SS18/SSX fusion serves as a crucial molecular diagnostic marker, aiding in the identification of synovial sarcoma. Moreover, SS18-SSX fusion proteins lack DNA-binding motifs but still effectively alter gene expression through epigenetic mechanisms. Despite the establishment of this fusion gene as a diagnostic marker, its prognostic value concerning survival rates remains debated. Additionally, novel antibodies targeting the SS18-SSX fusion protein have shown high specificity and sensitivity, offering potential advancements for diagnostic procedures and therapeutic strategies. Understanding the molecular and clinicopathological profiles influenced by this fusion gene is essential for developing targeted treatments for synovial sarcoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein SSXT; Protein SYT; SS18; SS18, nBAF chromatin remodeling complex subunit; SS18-SSX; Synovial sarcoma translocated to X chromosome protein; synovial sarcoma translocation, chromosome 18; synovial sarcoma, translocated to X chromosome; SYT; SYT-SSX1; SYTins; unnamed protein product
Gene Aliases: SMARCL1; SS18; SSXT; SYT
UniProt ID: (Human) Q15532
Entrez Gene ID: (Human) 6760
microtubule cytoskeleton organization
cell morphogenesis
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cytoskeleton organization
positive regulation of cell proliferation
response to xenobiotic stimulus
intracellular signal transduction
negative regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
neuronal stem cell population maintenance
positive regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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