Search

  • Order Status
  • Quick Order
  • Promos

NeoBiotechnologies

Cytokeratin, pan (Epithelial Marker) Recombinant Superclonal™ Antibody (MonoPoly/4999R)

View all (74) Cytokeratin Pan Type I/II antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

RBMP51-4999P1ABX

Applications
Tested Dilution
Publications

Western Blot (WB)

2-4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Superclonal

Type

Antibody

Clone

MonoPoly/4999R

Immunogen

Recombinant fragments and/or synthetic peptides of human Cytokeratin proteins (exact sequences are proprietary)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: Adeno- or Squamous carcinomas. HeLa or MCF-7 cells. Human skin

Cellular Location: Cytoplasm.

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 40-kDa keratin intermediate filament; 58 kda cytokeratin; 65 kDa cytokeratin; 67 kDa cytokeratin; cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-15; CK-19; CK-1B; CK-2P; CK-3; CK-5; CK-7; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7; cytokeratin 8; cytokeratin-17; cytokeratin-1B; cytokeratin-2e; cytokeratin-2P; cytokeratin-5; cytokeratin-8; cytoskeletal protein; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein K16; intermediate filament protein; K7; K1B; K2P; K76; K77; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type I, 40-kd; keratin-10; keratin-15, basic; keratin-15, beta; keratin-2 epidermis; keratin-2e; KRT1B; KRT5; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; sarcolectin; type I cytoskeletal 15; type II cytoskeletal 1b; type II keratin subunit protein; type II mesothelial keratin K7; type-II keratin Kb1; type-II keratin Kb2; type-II keratin Kb3; Type-II Keratin Kb39; type-II keratin Kb4; type-II keratin Kb5; type-II keratin Kb6; type-II keratin Kb7; type-II keratin Kb8; type-II keratin Kb9; unnamed protein product

View more View less

Gene Aliases: 39.1; AEI2; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1CO; K1CP; K1CS; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; KO; KPP; KRT16A; KRT1A; KRT1B; KRT2A; KRT2B; KRT2E; KRT2P; KRT5A; KRT6C; KRT6D; KRTE; MECD2; NEPPK; NFJ; PC1; PC2; PC3; PCHC1; SCL; WSN1; WSN2

View more View less

UniProt ID: (Human) P04264, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Human) P05783, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Human) P05787

View more View less

Entrez Gene ID: (Human) 3848, (Human) 3858, (Human) 3860, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3872, (Human) 3875, (Human) 3880, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 51350, (Human) 374454, (Human) 3856

View more View less

Function(s)
protein binding carbohydrate binding structural constituent of epidermis signaling receptor activity protein heterodimerization activity structural molecule activity structural constituent of cytoskeleton keratin filament binding scaffold protein binding RNA binding structural constituent of muscle cadherin binding involved in cell-cell adhesion macromolecular complex binding cytoskeletal protein binding
Process(es)
morphogenesis of an epithelium cytoskeleton organization epithelial cell differentiation regulation of translation in response to stress intermediate filament organization epidermis development keratinocyte differentiation hair cycle intermediate filament bundle assembly positive regulation of keratinocyte differentiation response to estrogen sarcomere organization positive regulation of cell growth hair follicle morphogenesis positive regulation of translation positive regulation of hair follicle development keratinization positive regulation of cell proliferation cell differentiation negative regulation of cell migration killing of cells of other organism wound healing defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of entry of bacterium into host cell negative regulation of epithelial cell differentiation negative regulation of keratinocyte differentiation response to mechanical stimulus regulation of cell migration regulation of protein localization intermediate filament polymerization anatomical structure morphogenesis Golgi to plasma membrane protein transport negative regulation of apoptotic process intermediate filament cytoskeleton organization cell-cell adhesion negative regulation of epithelial cell proliferation inflammatory response innate immune response keratinocyte migration establishment of skin barrier epithelium development negative regulation of hepatocyte apoptotic process positive regulation of epidermis development protein heterotetramerization cornification complement activation, lectin pathway response to oxidative stress fibrinolysis regulation of angiogenesis keratinocyte activation keratinocyte proliferation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support