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Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-64135. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: P130Cas-associated protein; p140Cap; SNAP-25-interacting protein; SNAP25-interacting protein; SNIP; SRC kinase signaling inhibitor 1
Gene Aliases: KIAA1684; P140; SNIP; SRCIN1
UniProt ID: (Human) Q9C0H9
Entrez Gene ID: (Human) 80725
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