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Invitrogen
Human CLIF (aa 465-526) Control Fragment Recombinant Protein
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Product Details
RP-105354
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
IVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILD
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (75%), Rat (75%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84690. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aryl hydrocarbon receptor nuclear translocator-like 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic helix-loop-helix ARNT-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; Brain and muscle ARNT-like 2; Class E basic helix-loop-helix protein 6; CLIF; CYCLE-like factor; Member of PAS protein 9; MGC149671; MGC149672; PAS domain-containing protein 9; transcription factor BMAL2
Gene Aliases: ARNTL2; BHLHE6; BMAL2; CLIF; MOP9; PASD9
UniProt ID: (Human) Q8WYA1
Entrez Gene ID: (Human) 56938
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