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Invitrogen
Human TAPP1 (aa 113-188) Control Fragment Recombinant Protein
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Product Details
RP-107371
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
ITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQ
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66719. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Phosphatidylinositol-4,5-bisphosphate 3-phosphatase adapter protein 1 (TAPP1) is a gene located on chromosome 1q25.2, encoding a protein involved in intracellular signaling pathways that regulate cellular processes such as proliferation, survival, and migration. TAPP1 is characterized by containing pleckstrin homology (PH) domains, which allow it to bind specifically to phosphoinositide lipids, particularly phosphatidylinositol (3,4) bisphosphate. This interaction is crucial for the localization of TAPP1 to cell membranes where it can act as an adaptor protein, modulating the activity of downstream signaling molecules and pathways. TAPP1 is expressed in various tissues and plays a role in immune cell function, influencing processes like cell motility and cytoskeletal dynamics. Research into TAPP1 focuses on its role in immune regulation and signaling, with implications for understanding its function in disease contexts such as cancer and autoimmune disorders where phosphoinositide signaling is disrupted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Pleckstrin homology domain-containing family A member 1; Tandem PH domain-containing protein 1; TAPP-1
Gene Aliases: PLEKHA1; TAPP1
UniProt ID: (Human) Q9HB21
Entrez Gene ID: (Human) 59338
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