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Invitrogen
Human SEMA4G (aa 32-105) Control Fragment Recombinant Protein
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Product Details
RP-95590
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
ATPRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCH
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (86%), Rat (86%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58357. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The SEMA4G gene encodes semaphorin 4G, a member of the semaphorin protein family known for their roles in cellular guidance, signaling, and development. Semaphorin 4G is involved in axonal guidance, where it influences the direction and growth of neurons by interacting with receptor complexes such as plexins. This interaction is critical in neural development, contributing to the proper formation of neural circuits by ensuring that neurons connect accurately and functionally. Beyond its role in the nervous system, SEMA4G also participates in immune responses, where it modulates the activity and migration of immune cells, influencing processes like inflammation and immune surveillance. This protein's modulation of cell-to-cell communication and migration extends to its implications in cancer, where altered semaphorin signaling can impact tumor progression and metastasis through changes in cell adhesion and migration properties. Research into SEMA4G continues to investigate its precise mechanisms and interactions, providing insights into therapeutic opportunities in neural disorders and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA1619FLJ20590; MGC102867; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; unnamed protein product
UniProt ID: (Human) Q9NTN9
Entrez Gene ID: (Human) 57715
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