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Invitrogen
Human GTDC1 (aa 344-442) Control Fragment Recombinant Protein
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Product Details
RP-96058
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
HWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAAL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (93%), Rat (93%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57774. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The GTDC1 (Glycosyltransferase-Like Domain Containing 1) gene encodes a protein that is hypothesized to function as a glycosyltransferase. This gene has been implicated in several crucial biological processes, particularly in the nervous system. The GTDC1 cDNA is 2954 base pairs in length, encoding a protein of 458 amino acids, and shows high expression in tissues such as the lung, spleen, testis, and peripheral blood leukocytes. Genetic studies have highlighted its potential role in developmental disorders, such as global developmental delay and delayed speech and language development, linked to microdeletions encompassing the GTDC1 gene. Disruption of GTDC1 expression has been shown to affect neural progenitor cells and neurons, indicating its significance in neural development. Additionally, the gene holds evolutionary conservation, sharing 75% and 37% identity with its mouse and fruit fly counterparts, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycosyltransferase-like 1; glycosyltransferase-like domain containing 1; Glycosyltransferase-like domain-containing protein 1; mannosyltransferase candidate; Mannosyltransferase-like protein Xa; Mat-Xa; QTMAN; tRNA-queuosine alpha-mannosyltransferase
Gene Aliases: GTDC1; Hmat-Xa; mat-Xa; QTMAN
UniProt ID: (Human) Q53SM7
Entrez Gene ID: (Human) 79712
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