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Fabgennix
Soluble Guanylyl Cyclase beta 1 Polyclonal Antibody
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FIGURE: 1 / 1
Soluble Guanylyl Cyclase beta 1 Antibody (SGCB-201AP) in IHC
Rat Cerebellum- Soluble Guanylate Cyclase beta 1 Primary Antibody: SGCB-201AP; 1:100 dilution in IHC Blocking Buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 5X magnification on Leica DM4000 microscope. FFPE section.
Product Details
SGCB-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 175-225 on rat guanylate cyclase soluble subunit beta-1 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta 1 sGC; GCS beta1; GCS beta3; GCS-beta-1; GCS-beta-3; GCS-beta1; GCS-beta3; GCSbeta1; GCSbeta3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; nitric oxide-sensitive guanylyl cyclase beta 1 subunit; NO-sensitive GC beta 1 subunit; NO-sensitive guanylyl cyclase beta 1 subunit; soluble guanylate cyclase beta-1 subunit; Soluble guanylate cyclase small subunit; unnamed protein product
Gene Aliases: GC-S-beta-1; GC-SB3; GCbeta1; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3; SGC
UniProt ID: (Human) Q02153, (Bovine) P16068, (Rat) P20595, (Mouse) O54865
Entrez Gene ID: (Human) 2983, (Bovine) 282433, (Rat) 25202, (Mouse) 54195
nucleotide binding
adenylate cyclase activity
guanylate cyclase activity
protein binding
GTP binding
lyase activity
phosphorus-oxygen lyase activity
heme binding
signaling receptor activity
macromolecular complex binding
metal ion binding
cytidylate cyclase activity
Hsp90 protein binding
nitric oxide binding
ion binding
protein heterodimerization activity
guanylate cyclase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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