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OriGene
PDE2A Monoclonal Antibody (OTI2A5), TrueMAB™
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Product Details
TA502349S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2A5
Immunogen
Full length human recombinant protein of human PDE2A produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.72 mg/mL
Amount
21.6 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; PDE2A1; PDE2A2; PED2A4; phosphodiesterase 2A, cGMP-stimulated; unnamed protein product
Gene Aliases: CGS-PDE; cGSPDE; IDDPADS; PDE2A; PDE2A1; PED2A4
UniProt ID: (Human) O00408
Entrez Gene ID: (Human) 5138
nucleotide binding
magnesium ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
hydrolase activity
cAMP binding
cGMP binding
TPR domain binding
phosphate ion binding
identical protein binding
protein homodimerization activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
negative regulation of transcription from RNA polymerase II promoter
heart valve development
ventricular septum development
signal transduction
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of gene expression
regulation of cGMP-mediated signaling
negative regulation of cGMP-mediated signaling
regulation of mitochondrion organization
cGMP-mediated signaling
monocyte differentiation
aorta development
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cAMP
cellular response to cGMP
cellular response to xenobiotic stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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