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FBXW7 Monoclonal Antibody (OTI2E12), TrueMAB™

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FBXW7 Monoclonal Antibody (OTI2E12), TrueMAB™

Product Details

TA802858

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2E12

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-354 of human FBXW7 produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: archipelago; Archipelago homolog; DKFZp686F23254; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FLJ11071; FLJ16457; hAgo; hCdc4; hCDC4; WD40 repeat-containing F-box protein; homolog of C elegans sel-10; SEL-10; similar to budding yeast CDC4; unnamed protein product; WD40 repeat-containing F-box protein

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Gene Aliases: AGO; CDC4; DEDHIL; FBW6; FBW7; FBX30; FBXO30; FBXW6; FBXW7; hAgo; hCdc4; SEL-10; SEL10

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UniProt ID: (Human) Q969H0

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Entrez Gene ID: (Human) 55294

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Function(s)
protein binding cyclin binding protein binding, bridging ubiquitin protein ligase binding identical protein binding ubiquitin binding phosphothreonine binding ubiquitin-protein transferase activator activity protein binding, bridging involved in substrate recognition for ubiquitination
Process(es)
G1/S transition of mitotic cell cycle vasculature development DNA repair cellular response to DNA damage stimulus sister chromatid cohesion regulation of mitotic cell cycle negative regulation of gene expression negative regulation of triglyceride biosynthetic process regulation of lipid storage ubiquitin homeostasis protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination regulation of protein stability negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization cellular response to UV regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of epidermal growth factor receptor signaling pathway negative regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter rhythmic process protein stabilization lipid homeostasis positive regulation of ERK1 and ERK2 cascade regulation of mitophagy positive regulation of proteasomal protein catabolic process regulation of cell cycle G1/S phase transition positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of protein targeting to mitochondrion negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of hepatocyte proliferation negative regulation of SREBP signaling pathway negative regulation of osteoclast development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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