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OriGene

EZH2 Monoclonal Antibody (OTI10B10), TrueMAB™

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EZH2 Monoclonal Antibody (OTI10B10), TrueMAB™

Product Details

TA803011

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Miscellaneous PubMed (Misc)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI10B10

Immunogen

Human recombinant protein fragment corresponding to amino acids 182-431 of human EZH2 ( NP_004447) produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Mutations affecting EZH2 can cause Weaver syndrome (WVS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: an; Enhancer of zeste homolog 2; enhancer of zeste homolog 2; transcription repressor; chromatin modifier; ENX 1; ENX-1; EZH 2; EZH-2; Histone-lysine N-methyltransferase EZH2; Lysine N-methyltransferase 6; OTTHUMP00000213774; OTTHUMP00000213778; OTTHUMP00000213779; OTTHUMP00000213780; unnamed protein product

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Gene Aliases: ENX-1; ENX1; EZH2; EZH2b; KMT6; KMT6A; WVS; WVS2

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UniProt ID: (Human) Q15910

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Entrez Gene ID: (Human) 2146

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription corepressor binding DNA binding chromatin binding transcription corepressor activity RNA binding protein binding methyltransferase activity protein-lysine N-methyltransferase activity transferase activity chromatin DNA binding nucleosome binding histone methyltransferase activity histone binding ribonucleoprotein complex binding sequence-specific DNA binding histone methyltransferase activity (H3-K27 specific) primary miRNA binding lncRNA binding histone H3 methyltransferase activity histone H3K27 trimethyltransferase activity promoter-specific chromatin binding
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling methylation-dependent chromatin silencing regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation epidermal cell differentiation regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition regulation of gliogenesis skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration cardiac muscle hypertrophy in response to stress cerebellar cortex development hippocampus development hemopoiesis B cell differentiation keratinocyte differentiation positive regulation of cell migration chromatin silencing by small RNA heterochromatin assembly telomeric heterochromatin assembly methylation response to estradiol negative regulation of transcription elongation from RNA polymerase II promoter cellular response to trichostatin A protein modification process hepatocyte homeostasis regulation of cell proliferation regulation of circadian rhythm positive regulation of MAP kinase activity positive regulation of GTPase activity negative regulation of epidermal cell differentiation negative regulation of keratinocyte differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway rhythmic process stem cell differentiation regulation of neurogenesis negative regulation of striated muscle cell differentiation synaptic transmission, GABAergic cellular response to hydrogen peroxide G1 to G0 transition protein localization to chromatin positive regulation of protein serine/threonine kinase activity regulation of kidney development liver regeneration facultative heterochromatin formation positive regulation of dendrite development negative regulation of cytokine production involved in inflammatory response positive regulation of cell cycle G1/S phase transition response to tetrachloromethane negative regulation of G1/S transition of mitotic cell cycle negative regulation of stem cell differentiation
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