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OriGene
HDAC9 Monoclonal Antibody (OTI6E2), TrueMAB™
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Product Details
TA805257
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI6E2
Immunogen
Human recombinant protein fragment corresponding to amino acids 181-460 of human HDAC9 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779K1053; HD7; HD9; hdac-9; histone deacetylase 4/5-related protein; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; protein deacetylase; unnamed protein product
Gene Aliases: ARCND4; HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; KIAA0744; MITR
UniProt ID: (Human) Q9UKV0
Entrez Gene ID: (Human) 9734
transcription corepressor activity
histone deacetylase activity
protein kinase C binding
protein binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
protein deacetylase activity
histone deacetylase activity (H4-K16 specific)
histone deacetylase binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
negative regulation of transcription from RNA polymerase II promoter
negative regulation of cytokine production
chromatin organization
inflammatory response
heart development
negative regulation of macromolecule biosynthetic process
B cell differentiation
cellular response to insulin stimulus
regulation of gene expression, epigenetic
B cell activation
cholesterol homeostasis
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
regulation of skeletal muscle fiber development
regulation of striated muscle cell differentiation
positive regulation of cell migration involved in sprouting angiogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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