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OriGene
RARA Monoclonal Antibody (OTI2D5), TrueMAB™
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FIGURE: 1 / 1
RARA Antibody (TA806242) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RARA (RC200430, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RARA. Positive lysates LY400350 (100 µg) and LC400350 (20 µg) can be purchased separately from OriGene.
Product Details
TA806242
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D5
Immunogen
Human recombinant protein fragment corresponding to amino acids 52-299 of human RARA produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nuclear receptor; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR Alpha; RAR-alpha; RARA; retinoic acid; retinoic acid receptor; Retinoic acid receptor alpha; retinoic acid receptor, alpha polypeptide; RRA; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product
Gene Aliases: NR1B1; RAR; RARA; RARalpha
UniProt ID: (Human) P10276
Entrez Gene ID: (Human) 5914
translation repressor activity, nucleic acid binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
transcription coactivator binding
retinoic acid binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
protein binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
histone deacetylase binding
protein kinase B binding
sequence-specific DNA binding
retinoic acid-responsive element binding
metal ion binding
mRNA 5'-UTR binding
protein kinase A binding
alpha-actinin binding
heterocyclic compound binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
neural tube closure
liver development
glandular epithelial cell development
outflow tract septum morphogenesis
growth plate cartilage development
regulation of transcription, DNA-templated
protein phosphorylation
germ cell development
spermatogenesis
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
negative regulation of gene expression
negative regulation of translation
hippocampus development
cell differentiation
prostate gland development
regulation of granulocyte differentiation
negative regulation of granulocyte differentiation
embryonic camera-type eye development
regulation of myelination
response to estradiol
response to retinoic acid
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
response to vitamin A
response to cytokine
multicellular organism growth
mRNA transcription from RNA polymerase II promoter
regulation of apoptotic process
negative regulation of apoptotic process
apoptotic cell clearance
response to ethanol
negative regulation of cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
retinoic acid receptor signaling pathway
positive regulation of binding
ventricular cardiac muscle cell differentiation
Sertoli cell fate commitment
limb development
face development
bone development
trachea cartilage development
chondroblast differentiation
negative regulation of cartilage development
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to estrogen stimulus
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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