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OriGene
FOXO4 Monoclonal Antibody (OTI10G3), TrueMAB™
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FIGURE: 1 / 1
FOXO4 Antibody (TA810612) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FOXO4 (RC213185, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FOXO4. Positive lysates LY401798 (100 µg) and LC401798 (20 µg) can be purchased separately from OriGene.
Product Details
TA810612
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI10G3
Immunogen
Human recombinant protein fragment corresponding to amino acids 206-505 of human FOXO4 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AFX; AFX1; AFXzeta; Fork head domain transcription factor AFX1; Forkhead box protein O4; FOX04b; FOXO4b; MGC120490; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497; unnamed protein product
Gene Aliases: AFX; AFX1; FOXO4; MLLT7
UniProt ID: (Human) P98177
Entrez Gene ID: (Human) 4303
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
enzyme binding
identical protein binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to oxidative stress
mitotic G2 DNA damage checkpoint
muscle organ development
negative regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of smooth muscle cell migration
negative regulation of angiogenesis
cell differentiation
response to nutrient levels
cellular response to oxidative stress
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
negative regulation of smooth muscle cell differentiation
negative regulation of G0 to G1 transition
protein K48-linked ubiquitination
response to water-immersion restraint stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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