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OriGene
DES Monoclonal Antibody (UMAB166), UltraMAB™
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Product Details
UM500107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
UMAB166
Immunogen
Full length human recombinant protein of human DES produced in E.coli.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiomyocyte intermediate filament protein; cardiomyopathy, dilated 1F (autosomal dominant); cardiomyopathy, dilated 1I; CMD1I; Desmin; epididymis secretory sperm binding protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament; intermediate filament protein; MFM1; muscle specific intermediate filament; SCPNK; unnamed protein product
Gene Aliases: CDCD3; CSM1; CSM2; DES; LGMD1D; LGMD1E; LGMD2R
UniProt ID: (Human) P17661
Entrez Gene ID: (Human) 1674
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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