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Alomone Labs, LTD

TRPV1 (VR1) Polyclonal Antibody

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TRPV1 (VR1) Polyclonal Antibody

Product Details

ACC-030-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)EDAEVFKDSMVPGEK, corresponding to amino acid residues 824-838 of rat TRPV1, Intracellular, C-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Capsaicin receptor; cation channel; DKFZp434K0220; ion channel; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; truncated capsaicin receptor protein; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor; VR1; VR1 receptor

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Gene Aliases: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1

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UniProt ID: (Human) Q8NER1, (Rat) O35433, (Mouse) Q704Y3

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Entrez Gene ID: (Human) 7442, (Rat) 83810, (Mouse) 193034

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Function(s)
nucleotide binding transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity excitatory extracellular ligand-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding calmodulin binding ATP binding calcium-release channel activity phosphatidylinositol binding metal ion binding phosphoprotein binding temperature-gated ion channel activity cation channel activity cation transmembrane transporter activity ligand-gated ion channel activity chloride channel regulator activity identical protein binding ion channel
Process(es)
negative regulation of transcription from RNA polymerase II promoter temperature homeostasis fever generation diet induced thermogenesis peptide secretion lipid metabolic process ion transport calcium ion transport cell surface receptor signaling pathway chemosensory behavior response to pH response to heat urinary bladder smooth muscle contraction sensory perception of pain calcium-mediated signaling ion transmembrane transport cellular response to heat response to pain behavioral response to pain sensory perception of taste sensory perception of mechanical stimulus thermoception detection of temperature stimulus involved in thermoception detection of temperature stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception of pain protein homotetramerization transmembrane transport excitatory postsynaptic potential smooth muscle contraction involved in micturition calcium ion transmembrane transport cellular response to alkaloid cellular response to ATP cellular response to acidic pH calcium ion import across plasma membrane response to capsazepine calcium ion import into cytosol microglial cell activation inflammatory response signal transduction positive regulation of cytosolic calcium ion concentration response to organonitrogen compound glutamate secretion positive regulation of apoptotic process response to peptide hormone positive regulation of nitric oxide biosynthetic process positive regulation of gastric acid secretion cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to temperature stimulus negative regulation of establishment of blood-brain barrier cellular response to nerve growth factor stimulus transport cation transport catagen cation transmembrane transport
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